Todays Equity Focus is Marina Biotech, Inc. (OTCMKTS:MRNA)

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Marina Biotech, Inc. (OTCMKTS:MRNA) has seen a recent surge in trading volume trading over 1mm shares the other day and popping to highs near $0.50; a big move up since its recent $0.21 lows.

MRNA used to be a high flyer on the NASDAQ Stock Exchange and as everyone knows; ex big board stocks that hit the bb’s tend to make highly explosive moves which is exactly what MRNA did early last year running from $0.20 base to highs of $1.75.

Marina Biotech, Inc. (OTCMKTS:MRNA) bills itself as a leading nucleic acid-based drug discovery and development company focused on rare diseases. The Company is focused on the development and commercialization of oligonucleotide-based therapeutics utilizing multiple mechanisms of action including RNA interference and messenger RNA translational blocking.

MRNA broad drug discovery technologies provide the ability to develop proprietary single and double-stranded nucleic acid therapeutics including siRNAs, microRNA mimics, antagomirs, and antisense compounds, including messengerRNA therapeutics. These technologies were built via a roll-up strategy to discover and develop different types of nucleic acid therapeutics in order to modulate (up or down) a specific protein(s) which is either being produced too much or too little thereby causing a particular disease.

MRNA pipeline currently includes a clinical program in Familial Adenomatous Polyposis (a precancerous syndrome) and a preclinical program in myotonic dystrophy. Marina Biotech’s goal is to improve human health through the development of RNAi- and oligonucleotide-based compounds and drug delivery technologies that together provide superior therapeutic options for patients. The Company’s novel chemistries and other delivery technologies have been validated through license agreements with Roche, Novartis, MiNA Therapeutics, Monsanto, and Tekmira.

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In November MRNA said it received a milestone payment, in the amount of $200,000, from its licensee, MiNA Therapeutics Limited (MiNA), a privately-held biotechnology company pioneering short activating RNA (saRNA) as therapeutic agents for the treatment of human diseases.

CEO Michael French said “We are extremely pleased with MiNA’s progress as the forerunner in the development of saRNA-based therapeutics. Further, I believe the rapid advancement of their technology continues to demonstrate the versatility of SMARTICLES for the safe and effective delivery of nucleic acid compounds.”

On November 18 MRNA announced its SMARTICLES® licensee Mirna Therapeutics, Inc. (NASDAQ: MIRN) of Austin, TX, recently announced the presentation of interim results from its ongoing Phase I clinical trial of MRX34, Mirna’s lead therapeutic candidate. Mirna’s poster presentation was titled, “Safety, tolerability, and clinical activity of MRX34, the first-in-class liposomal miR-34 mimic, in patients with advanced solid tumors” and presented on November 8, 2015 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, MA. The poster reported interim Phase I clinical results for MRX34 from 75 patients with advanced solid tumors.

In addition, SMARTICLES licensee MiNA Therapeutics Limited recently announced the presentation of pre-clinical data on its MTL-CEBPA program in which the compound was shown to improve several markers of liver function in a rat model of liver failure. MiNA’s oral presentation was titled, “Systemic administration of novel development candidate, MTL-CEBPA, up-regulates the liver enriched transcription factor C/EBP-α, and reverses CCI4-induced liver failure in vivo” and presented on November 16, 2015 at the 2015 American Association for the Study of Liver Diseases (AASLD) Liver Meeting in San Francisco, CA.

CEO Michael French said “We are extremely pleased with the clinical and preclinical progress of SMARTICLES-delivered nucleic acid compounds. Over the past 30 days, ProNAi Therapeutics announced the initiation of their Brighton Phase II trial, Mirna Therapeutics announced interim results of their Phase I trial and MiNA Therapeutics announced positive preclinical results which they believe will allow them to advance their program into the clinic in 2016. We look forward to the continued positive progress of these programs and expect to complete additional similar SMARTICLES licenses in the future.”

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Currently trading at a $9.5 million market valuation MRNA has $1.8 million in the treasury, no revenues to date and manageable debt. There are plenty of reasons to get excited about MRNA here; as stated MRNA pipeline currently includes a clinical program in Familial Adenomatous Polyposis and a preclinical program in myotonic dystrophy. The stock is also an ex-NASDAQ high flyer with a history of explosive moves running from $0.20 to $1.75 in early 2014. We will be updating on MRNA when more details emerge so make sure you are subscribed to Microcapdaily so you know what’s going on with MRNA.

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Disclosure: we hold no position in MRNA either long or short and we have not been compensated for this article.

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2 Comments

  1. I’ve watched so many people get fried with MRNA, thank’s to my Stock Radar focused on stocks below $10 with Volume ??? it caught my eye at $.19 to which I bought at $.22-$.30 because these type of Pumps are easy to recognize to someone who only trades BB, Pink Sheet-Gray Market Paper. Recently after trading KLIO I bought MRNA hoping the Gang who moves this stock would show up to which they did! Trading MRNA is a delicate job, never short a stock like MRNA unless you want to blow up like KLIO Trader did.

    After churning MRNA for two years its a great way to make .10-$.20 if their Smarticles Frosted Flakes tech has good news. I hope we blast off like KLIO did because I will become rich, all my shares are paid for by selling at $1.50-$1.69 when all the Pumpers pushed it towards $2.00 with no reason for such a price spike. Also I enjoy watching people get stuck in MRNA because their impatient or realize by Margin that “MRNA is not considered a Margin-able Asset so they have to sell and the spread is always high! Thank You MRNA and keep them people coming and selling back to us!

  2. Did you catch IVOB or CTCC in their early stage of their moves, we have had a very good Year trading Pink Sheets, BB and Gray dudes, a very good year! Hope you have a good Holiday, don’t take this stock off your screen because you will get a chance to “play the spread” and enjoy the churn only to watch it break. I mentioned I traded from $.22 to $.30 early in the game. Watching it trade between Traders and knowing how a Pump is orchestrated is what all OTC Stock Traders need to Master.

    1. Never put a ton of capital in a stock!

    2. Don’t carry over a OTC Stock Short Overnight, buy and sell throughout the day because they provide plenty of fun. My trades on MRNA, after falling from $1.75 to $.60 again, I started to buy and sell, buy and sell having fun. When it fell to $.20 again for a odd reason I had no inventory, a good rule is to watch MRNA and notice when people (LIke Last Week’s weird volume and weird trades happen) because its time to sell to those guys pushing the spike up and buy back when they push it back down by $.15 during the same day!

    MRNA is fun because those who are promoting this stock have no idea, my two cousins work for the CDC as phDs in Molecular Biology, when they tell me its time to load up on this form of gene-tweaking I will buy a massive block!

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